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Archive for October, 2011
If you perceive of the body as a microcosm of all of creation, you had better pay attention to the universe when you are treating a patient. The medieval sensibility closely linked the stars and the humors of the body. This famous, hand-colored illustration of “zodiac man” comes from a 1500 printing of Joannes de Ketham’s Fasciculus Medicinae. Originally printed nine years earlier, it is thought to be the first medical textbook in the era of print (click here for more).
This year’s Nobel Prize in Physiology or Medicine went to Ralph M. Steinman “for his discovery of the dendritic cell and its role in adaptive immunity,” and to Bruce A. Beutler and Jules A. Hoffmann “for their discoveries concerning the activation of innate immunity.”
Thanks to our recent acquisition of the digital archives of many biomedical journals, Dartmouth/DHMC readers can access the key articles describing the research that led the Nobel Foundation to award the prize to Steinman, Beutler, and Hoffmann:
- Poltorak A, He X, Smirnova I, Liu MY, Van Huffel C, Du X, Birdwell D, Alejos E, Silva M, Galanos C, Freudenberg M, Ricciardi-Castagnoli P, Layton B, Beutler B. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene. Science 1998;282:2085-2088.
- Lemaitre B, Nicolas E, Michaut L, Reichhart JM, Hoffmann JA. The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in drosophila adults. Cell 1996;86:973-983.
- Steinman RM, Cohn ZA. Identification of a novel cell type in peripheral lymphoid organs of mice. J Exp Med 1973;137:1142-1162.
- Steinman RM, Witmer MD. Lymphoid dendritic cells are potent stimulators of the primary mixed leukocyte reaction in mice. Proc Natl Acad Sci USA 1978;75:5132-5136.
- Schuler G, Steinman RM. Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro. J Exp Med 1985;161:526-546.
For more information about this year’s prizes:
With Halloween just around the corner, there are a few things to keep in mind to remain healthy and safe. This exciting time of year for little ones can sometimes result in inconveniences like a tummy ache or something more unfortunate such as an injury.
First the Healthday News Service explains that “the number of U.S. kids injured on Halloween is scary.” Their article dated October 9, 2011 states that “experts warn that children are at 4 times the risk of being hit by a car on October 31st than any other night.” Click here for the full article.
Also, as described in The Science of the Total Environment (March, 2009), “Seasonal and holiday items are inexpensive and often directed specifically toward children, yet the use of lead paints in these products has not been widely recognized.” The objective of this study was to determine just how much lead is found in these types of seasonal products.
And lastly, some of you may recall hearing of local hospitals offering to screen your child’s Halloween candy. This has been going on for many years. The study mentioned in The Annals of Emergency Medicine (October, 1993), explains that “Data were collected from area medical centers that were screening Halloween candy. The ability to detect small sharp items was tested at five centers.”
A few examples of what could go badly. Of course, having eaten too many sweets will result in an upset tummy almost every time! Here’s to an enjoyable and safe Halloween holiday.
The Biomedical Libraries are now hosting the work of three artists:
- The Art at Dana program is pleased to announce a new exhibition of works by Beth Links and Susan Welihan. Beth, a second year medical student, creates colorful fabric sculptures. Susan, a program manager at the Norris Cotton Cancer Center, is showing collage pieces made from bits of ceramic. This exhibition will run through December in the quiet reading area on the first floor of the Dana Biomedical Library. Dana Library is open Monday through Friday 7:30am to midnight, Saturday 9:00am to midnight, and Sunday noon to midnight.
- The Matthews-Fuller Health Sciences Library is showing the photographs of Sandy Adams. A black and white photographic journey from the mind’s eye into an intimate, real-world environment of form, light, and texture. Matthews-Fuller Library is open Monday through Thursday 8:00am to 7:00pm, Friday 8:00am to 6:00pm, Saturday 9:00am to 5:00pm, and Sunday 11:00am to 7:00pm.
Please visit our Exhibits web page for more information.
Kangaroo – Portrait of an Extraordinary Animal
QL737.M35 J33 2010
Though often depicted in movies as a comedic animal – kangaroos are simply phenomenal all terrain marsupials that can move at speed, survive the most difficult arid conditions, and carry their offspring in complete safety. This book by Stephen Jackson looks at the engaging kangaroo and examines the different variations of the species, from tiny specimens living in arboreal areas to the familiar grassland kangaroos. This book also looks at the conservation of the species in the wild. This is a remarkable monograph possessing great depth of research on a fascinating animal.
Engineering Animals: How Life Works
QP31.2 .D46 2011
The authors of this intriguing monograph look at animals and humans as an engineered system. Through countless generations of selection and continual refinement, animal species have become seamlessly integrated into their natural environment as finely crafted mechanisms. The authors look at the natural laws of physics to answer the question of how large or how fast animals can be. They look at animal behavior as the process by which animals survive and succeed in the on-going challenges of nature. This book is an insightful look at animals as symbiotic and well-crafted mechanisms in their shifting natural environments.
Animal Tool Behavior
QL785 .B32 2011
Humans are not alone in the creation and use of tools. Chimpanzees, dolphins, and even crows use tools to survive in the wild. This book looks at the several animal species that use simple tools and shows how they have adapted to these successful behaviors as tool makers. From the octopus to the rain forest orangutan, this monograph is a fascinating examination of tool making and use in the natural world.
Writing for Publication in Nursing
RT24 .O35 2011
Writing for publication can be a challenging process, and this book is a useful text that can work as a guide for the nursing subject writer. This book is a step by step procedural manual from coming up with creative ideas to developing and crafting a finished piece of writing. This book helps the writer identify their audience, establish awareness of evidence-based practice, and relay current information. This book is an enormously helpful work for those writing on nursing research topics.
The Journey Through Cancer
Matthews-Fuller Library: Consumer Health
RC263 .G426 2000
There are few books on the subject of cancer that can so readily help the reader with dealing with the cancer diagnosis and subsequent treatment as this insightful work by a gifted oncologist. This monograph is a helpful and detailed seven step process that will give the reader guidance and help to establish goals in cancer treatment. With fifteen years on insight helping patients, this author has a deep understanding of cancer and its impact on the patient.
Real Life with Celiac Disease
Matthews-Fuller Library: Consumer Health
RC862.C44 D46 2010
This book is a complete guide to living with celiac disease. The authors look at all aspects of this challenging condition and identify the many facets of living a healthy life by accepting a gluten-free diet. For those who are challenged with this condition, this book is an invaluable resource that can help you deal with the difficult day to day realities of celiac disease.